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Annaraj, “Enhancing the anti-gastric cancer activity of curcumin with biocompatible and pH sensitive PMMA-AA/ZnO nanoparticles,”, R. Dhivya, J. Ranjani, P. K. Bowen, J. Rajendhran, J. Mayandi, and J. Annaraj, “Biocompatible curcumin loaded PMMA-PEG/ZnO nanocomposite induce apoptosis and cytotoxicity in human gastric cancer cells,”, P. Patel, K. Kansara, V. A. Senapati, R. Shanker, A. Dhawan, and A. Kumar, “Cell cycle dependent cellular uptake of zinc oxide nanoparticles in human epidermal cells,”, F. Namvar, S. Azizi, H. S. Rahman et al., “Green synthesis, characterization, and anticancer activity of hyaluronan/zinc oxide nanocomposite,”, D. F. Stowe and A. K. S. Camara, “Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function,”, E. Moghimipour, M. Rezaei, Z. Ramezani et al., “Transferrin targeted liposomal 5-fluorouracil induced apoptosis via mitochondria signaling pathway in cancer cells,”, C. Y. Guo, L. Sun, X. P. Chen, and D. S. Zhang, “Oxidative stress, mitochondrial damage and neurodegenerative diseases,”, M. Chandrasekaran and M. Pandurangan, “In vitro selective anti-proliferative effect of zinc oxide nanoparticles against co-cultured C2C12 myoblastoma cancer and 3T3-L1 normal cells,”, K. N. Yu, T. J. Yoon, A. Minai-Tehrani et al., “Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation,”, S. Hackenberg, A. Scherzed, A. Gohla et al., “Nanoparticle-induced photocatalytic head and neck squamous cell carcinoma cell death is associated with autophagy,”, M. Arakha, J. Roy, P. S. Nayak, B. Mallick, and S. Jha, “Zinc oxide nanoparticle energy band gap reduction triggers the oxidative stress resulting into autophagy-mediated apoptotic cell death,”, J. Zhang, X. Qin, B. Wang et al., “Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells,”, N. Erathodiyil and J. Y. 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Ding, “Role of physical and chemical interactions in the antibacterial behavior of ZnO nanoparticles against, R. K. Dutta, B. P. Nenavathu, M. K. Gangishetty, and A. V. Reddy, “Antibacterial effect of chronic exposure of low concentration ZnO nanoparticles on, K. M. Reddy, K. Feris, J. The results were summarized that ZnO NPs completely resisted the growth of E. coli at concentrations of about 3.4 mM but inhibited growth of S. aureus at much lower concentrations (≥1 mM). Chem. The HA/ZnO nanocomposites caused morphological changes and inhibited proliferation of cancer cells (pancreatic adenocarcinoma PANC-1 cell, ovarian adenocarcinoma CaOV-3 cell, colonic adenocarcinoma COLO205 cell, and acute promyelocytic leukemia HL-60 cell) in dose- and time-dependent manner. Furthermore, coupled with ultraviolet (UV) illumination, Dox-ZnO nanocomplexes caused more cell death through photocatalytic properties and synergistically triggered caspase-dependent apoptosis. prepared stable aqueous ZnO@polymer core-shell nanoparticles (ZnO@poly(MAA-co-PEGMEMA))for the first time. By continuing you agree to the use of cookies. The anti-inflammatory activity of ZnO NPs is not confined to atopic dermatitis treatment but has also shown to be very effective for other inflammatory diseases. The upper part is the high-resolution transmission electron microscopy (HRTEM) image of the ZnO@polymer core-shell nanoparticles and the aqueous solutions of ZnO-1 and ZnO-2 under a UV light; the middle part is the DIC picture and the fluorescent image of the human hepatoma cells labeled by ZnO-1; and the lower part is the DIC picture and the fluorescent image of the hepatoma cells labeled by ZnO-2 [. Download PDF Copy; Request Quote; Written by AZoNano Jul 10 2013. Zinc is a trace element and abundantly found mineral in all human tissues and tissue fluids. Kitture et al. They also detected the antibacterial activity of the ZnO NPs in cholera toxin (CT) mouse models. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. Zinc oxide nanoparticles (ZnO NPs) had been in recent studies due to its large bandwidth and high exciton binding energy and it has potential applications like antibacterial, antifungal, anti-diabetic, anti-inflammatory, wound healing, antioxidant and optic properties. 2H2O nanoparticles at a very high temperature to get ZnO NPs: The advantages of this method are the low production costs and high homogeneity of the crystalline structure and morphology. The Phβ-GBP-ZnO NPs were spherical in shape with a particle size of 20–50 nm and restrained the growth of S. aureus and P. vulgaris. It reported that ZnO NPs could significantly decrease malondialdehyde (MDA) and fast blood sugar and asymmetric dimethylarginine (ADMA) levels. The synthesized sample was calcined at different temperatures for 2 h. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and proton-induced X-ray emission (PIXE) … The amount of zinc oxide nanoparticles used in everyday products is a potential hazard at both professional and consumer levels. The … After culture with SMMC-7721 hepatocarcinoma cells, Dox-ZnO nanocomplexes acted as an efficient drug delivery system for importing Dox into SMMC-7721 cells and enhanced the cellular uptake of Dox dramatically. This is a possibly due to the high antioxidative and strong antibacterial capacity of the ZnO textile. explored the effects of ZnO NPs on human liver cancer HepG2 cells and its possible pharmacological mechanism [42]. Reddy prepared ZnO NPs with sizes of ∼13 nm and examined their antibacterial (E. coli and S. aureus) activities [78]. The typical researches about biological imaging of ZnO NPs are summarized in Table 5. Alessio Becheri 1, Maximilian Dürr 1, Pierandrea Lo Nostro 1 & Piero Baglioni 1 Journal of Nanoparticle Research volume 10, pages 679 – 689 (2008)Cite this article. Schematic illustration of antibacterial activity of ZnO NPs. They treated drug sensitive leukemia line K562 cells with ZnO nanosheets, and the yellow-orange light emission was clearly observed around or inside the cells under UV irradiation (365 nm) at room temperature [122]. It appeared to increase the toxicity of the ZnO NPs to breast cancer MCF-7 and MDA-MB-231 cells at lower doses. So we can believe that eluted Zn2+ from ZnO NPs also take a key role in antibacterial action. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface … This autophagy induction was positively correlated with the dissolution of ZnO NPs in lysosomes to release zinc ions, and zinc ions released from ZnO NPs were able to damage lysosomes, leading to impaired autophagic flux and mitochondria. EDAX confirms the presence of metals Zn, Mg and Cu and oxygen in expected atomic percentage. Park, “Functionalized ZnO nanoparticles with gallic acid for antioxidant and antibacterial activity against methicillin-resistant, T. Ohira and O. Yamamoto, “Correlation between antibacterial activity and crystallite size on ceramics,”, S. Sarwar, A. Ali, M. Pal, and P. Chakrabarti, “Zinc oxide nanoparticles provide anti-cholera activity by disrupting the interaction of cholera toxin with the human GM1 receptor,”, S. N. Seclen, M. E. Rosas, A. J. Arias, and C. A. Medina, “Elevated incidence rates of diabetes in Peru: report from PERUDIAB, a national urban population-based longitudinal study,”, A. Nazarizadeh and S. Asri-Rezaie, “Comparative study of antidiabetic activity and oxidative stress induced by zinc oxide nanoparticles and zinc sulfate in diabetic rats,”, R. D. Umrani and K. M. Paknikar, “Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats,”, R. Malizia, A. Scorsone, P. D’Angelo, C. Lo Pinto, L. Pitrolo, and C. Giordano, “Zinc deficiency and cell-mediated and humoral autoimmunity of insulin-dependent diabetes in thalassemic subjects,”, R. Kitture, K. Chordiya, S. Gaware et al., “ZnO nanoparticles-red sandalwood conjugate: a promising anti-diabetic agent,”, J. Hussein, M. El-Banna, T. A. Razik, and M. E. El-Naggar, “Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications,”, A. Bayrami, S. Parvinroo, A. Habibi-Yangjeh, and S. Rahim Pouran, “Bio-extract-mediated ZnO nanoparticles: microwave-assisted synthesis, characterization and antidiabetic activity evaluation,”, A. Amiri, R. A. F. Dehkordi, M. S. Heidarnejad, and M. J. Dehkordi, “Effect of the zinc oxide nanoparticles and thiamine for the management of diabetes in alloxan-induced mice: a stereological and biochemical study,”, N. S. Wahba, S. F. Shaban, A. 3 Altmetric. Zinc oxide (ZnO), as a material with attractive properties, has attracted great interest worldwide, particularly owing to the implementation of the synthesis of nano-sized particles. It found that ZnO NPs with small dimensions at higher doses (3 and 10 mg/kg) had a much greater antidiabetic effect compared to ZnSO4 (30 mg/kg). We use cookies to help provide and enhance our service and tailor content and ads. ZnO NPs have exhibited promising biomedical applications based on its anticancer, antibacterial, antidiabetic, anti-inflammatory, drug delivery, as well as bioimaging activity. MgO most of the particles are in the range 10-20 nm with spherical morphology. Moghaddam et al. In general, the anticancer activity of nanoscaled ZnO materials with prominent functionality may provide a new opportunity for exploiting ZnO NPs in treating cancer diseases. Ilves et al. Jiang et al. Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the impairment of the skin-barrier functions, which was involved with complex interaction between genetic and environmental factors [112, 113]. Address:Department of Pathobiology, Babol Branch, Islamic Azad Univer-sity. Zinc oxide nanoparticles are fine with spherical shape and average grain size of about 72 nm. Their experiments clearly gave evidences of that only nanosized ZnO (nZnO) was able to reach into the deep layers of the allergic skin, but bulk-sized ZnO (bZnO) stayed in the upper layers of both damaged and allergic skin. ZnO nanostructures were successfully attached onto or penetrated into the cells, which suggested that ZnO nanosheets with visible yellow-orange emission could act as a feasible label for the bioimaging. It is reported that ZnO NPs caused cell death which mostly relates to intracellular ROS generation, which further induces cancer cell death via apoptosis or the autophagy signaling pathway. 5 clearly shows that the zinc oxide nanoparticles obtained by refluxing diethylene glycol and triethylene glycol for 2 h and 3 h in presence and in absence of sodium acetate have uniform shape and size with different morphology. Zinc oxide (ZnO) is an inorganic compound widely used in everyday applications. Different types of drugs such as doxorubicin, paclitaxel, curcumin, and baicalin or DNA fragments could be loaded onto the ZnO NPs to show better solubility, higher toxicity compared with individual agents, and effective delivery into cancer cells [48, 67–69]. Therefore, in subsequent research work, we should attach more importance to their molecular mechanism in vitro and vivo and overcome its limitations in cancer therapy. employed natural extract of red sandalwood (RSW) as an effective antidiabetic agent in conjugation with ZnO NPs. The ZnO-NPs demonstrated a far superior antioxidant and enzyme inhibition activity with a significantly lower IC50 value as compared to a standard reference. In addition, Phβ-GBP-ZnO NPs could alter cell membrane permeability and trigger high level of ROS formation both in S. aureus and P. vulgaris [87]. produced hyaluronan/ZnO nanocomposite (HA/ZnO) through green synthesis for the first time for cancer treatment [57]. The aim of the study was to assess the toxicity of zinc oxide … The antibacterial activity may involve the accumulation of ZnO NPs in the outer membrane or cytoplasm of bacterial cells and trigger Zn2+ release, which would cause bacterial cell membrane disintegration, membrane protein damage, and genomic instability, resulting in the death of bacterial cells [75–77]. Abstract Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. Arakha et al. Its microcrystals are very efficient light absorbers in the UVA and UVB region of spectra due to wide bandgap. The loss of the mitochondrial membrane potential could open outer membrane pores which would result in the release of some related apoptotic proteins including cytochrome c into the cytosol and activate the caspase. It was found that zinc oxide calcined from 400°C to 550°C exhibited the same crystallite growth rate (38–50 nm) [22]. It was found that ZnO NPs could induce the CT secondary structure collapsed gradually and interact with CT by interrupting CT binding with the GM1 anglioside receptor [98]. Optical properties can be tuned by doping. Jiang et al. ZnO NPs less than 100 nm are considered to be relatively biocompatible, which support their biomedical applications and represent a powerful property in promoting the biomedical research. Zinc Oxide (ZnO) Nanoparticles – Properties & Applications. Biosynthetic and environment friendly technology for the synthesis of ZnO NPs are believed to be more ecofriendly, economical (low priced), nontoxic, and biocompatible than chemical and physical methods. Using nanoparticles in targeted drug delivery provides exciting opportunities for much more safety and effective cancer treatment. To stabilize ZnO NPs in water, they encapsulated the ZnO NPs with silica to form ZnO@silica core-shell nanostructures. It showed that ZnO NPs with an average size about 30 nm caused cell death by directly contacting with the phospholipid bilayer of the membrane, destroying the membrane integrity. Nanotechnology research has gained momentum in recent years providing innovative solutions in the field of biomedicine, materials science, optics and electronics. A … The mitochondrial electron transport chain is known to be associated with intracellular ROS generation, and anticancer agents entering into cancer cells could destroy the electron transport chain and release huge amounts of ROS [58, 59]. Overall, the results suggested that the present green synthesized Neem based ZnO-NPs could be developed as a therapeutic agent with antioxidant, enzyme inhibition and strong antibacterial potential against antibiotic-resistant bacteria that can be safely administered. Compared to bare ZnO NPs, RGD peptide modification also increased the targeting effects of ZnO NPs on integrin αvβ3 receptors overexpressed MDA-MB-231 cells [47]. Since the advent of nanoparticles and considering these biological activities of zinc ions, the anti-inflammatory effects of ZnO NPs have also attracted much attention. Chandrasekaran and Pandurangan investigated the cytotoxicity of ZnO nanoparticles against cocultured C2C12 myoblastoma cancer cells and 3T3-L1 adipocytes, which showed that ZnO NPs could be more cytotoxic to C2C12 myoblastoma cancer cells than 3T3-L1 cells. Due to inherent toxicity of ZnO NPs, they possess strong inhibition effects against cancerous cell and bacteria, by inducing intracellular ROS generation and activating apoptotic signaling pathway, which makes ZnO NPs a potential candidate as anticancer and antibacterial agents. Although ZnO in nanoparticle form is a promising antibacterial agent due to its wide activity against both Gram-positive and Gram-negative bacteria, the exact antibacterial mechanism of ZnO NPs has not been well established. Fig. Copyright © 2018 Jinhuan Jiang et al. A. Ruszkiewicz, A. Pinkas, B. Ferrer, T. V. Peres, A. Tsatsakis, and M. Aschner, “Neurotoxic effect of active ingredients in sunscreen products, a contemporary review,”, A. Kolodziejczak-Radzimska and T. Jesionowski, “Zinc oxide–from synthesis to application: a review,”, S. Sahoo, M. Maiti, A. Ganguly, J. J. George, and A. K. Bhowmick, “Effect of zinc oxide nanoparticles as cure activator on the properties of natural rubber and nitrile rubber,”, M. D. Newman, M. Stotland, and J. I. Ellis, “The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens,”, A. Hatamie, A. Khan, M. Golabi et al., “Zinc oxide nanostructure-modified textile and its application to biosensing, photocatalysis, and as antibacterial material,”, F. X. Xiao, S. F. Hung, H. B. Tao, J. Miao, H. B. Yang, and B. Liu, “Spatially branched hierarchical ZnO nanorod-TiO, J. W. Rasmussen, E. Martinez, P. Louka, and D. G. Wingett, “Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications,”, Z. Y. Zhang and H. M. Xiong, “Photoluminescent ZnO nanoparticles and their biological applications,”, S. Kim, S. Y. Lee, and H. J. Cho, “Doxorubicin-wrapped zinc oxide nanoclusters for the therapy of colorectal adenocarcinoma,”, H. M. Xiong, “ZnO nanoparticles applied to bioimaging and drug delivery,”, M. A. Majeed Khan, M. Wasi Khan, M. Alhoshan, M. S. AlSalhi, and A. S. Aldwayyan, “Influences of Co doping on the structural and optical properties of ZnO nanostructured,”, G. Bisht, S. Rayamajhi, B. Kc, S. N. Paudel, D. Karna, and B. G. Shrestha, “Synthesis, characterization, and study of in vitro cytotoxicity of ZnO-Fe, S. Bettini, R. Pagano, V. Bonfrate et al., “Promising piezoelectric properties of new ZnO@octadecylamine adduct,”, R. Pagano, A. Quarta, S. Pal, A. Licciulli, L. Valli, and S. Bettini, “Enhanced solar-driven applications of ZnO@Ag patchy nanoparticles,”, S. Bettini, R. Pagano, L. Valli, and G. Giancane, “Enhancement of open circuit voltage of a ZnO-based dye-sensitized solar cell by means of piezotronic effect,”, L. Spanhel and M. A. Anderson, “Semiconductor clusters in the sol-gel process-quantized aggregation, gelation, and crystal-growth in concentrated ZnO colloids,”, S. Rani, P. Suri, P. Shishodia, and R. Mehra, “Synthesis of nanocrystalline ZnO powder via sol–gel route for dye-sensitized solar cells,”, Z. J. Wang, H. M. Zhang, L. G. Zhang, J. S. Yuan, S. G. Yan, and C. Y. Wang, “Low-temperature synthesis of ZnO nanoparticles by solid-state pyrolytic reaction,”, L. Shen, N. Bao, K. Yanagisawa, K. Domen, A. Gupta, and C. A. Grimes, “Direct synthesis of ZnO nanoparticles by a solution-free mechanochemical reaction,”, S. K. Pardeshi and A. It has been shown that maximum exposure concentration of zinc oxide (125 mg/l) suspension released 6.8 mg/l of Zn 2+ ions. By targeting the specific sites of cancer cells, nanoparticle-based drug delivery could reduce the overall amount of drugs used and thus minimize undesirable side effects [9, 66]. fabricated ZnO NPs using the chemical precipitation method and further evaluated their anticancer activity [64], which found that ZnO NPs with different sizes could obviously inhibit the proliferation of fibrosarcoma HT1080 cells. The obtained ZnO@silica core-shell nanoparticles exhibited excellent water stability, and the visible emissions of ZnO were retained. As far as method of formation is concerned, ZnO NPs can be synthesized by several chemical methods such as precipitation method, vapor transport method, and hydrothermal process. Using a simple sol-gel method, Xiong et al. Hence, ZnO NPs also have the potential to be utilized for anti-inflammatory treatment. Hence, autophagy not only promotes cell survival but also activates lethal mechanisms in cancer cells, thus be considered as an important event in nanoparticle-induced cytotoxicity. These results afforded valuable insights into the mechanism of ZnO NPs-induced apoptosis in human liver HepG2 cells. We … In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. Aiming at the development of nanomedicine against cholera, Sarwar et al. 1. Crossref Encouraging, HA/ZnO nanocomposite treatment for 72 hours did not cause toxicity to the normal human lung fibroblast (MRC-5) cell line. Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. Epidemic disease cholera, a serious diarrheal disease caused by the intestinal infection of Gram-negative bacterium V. cholera, mainly affects populations in the developing countries [81, 94]. Review articles are excluded from this waiver policy. Physical and chemical methods for ZnO NPs preparations have widely developed. Essentially, nanoparticles are a varied … Research Paper; Published: 30 October 2007; Synthesis and characterization of zinc oxide nanoparticles: application to textiles as UV-absorbers . Toxicity of zinc oxide nanoparticles is concentration and solubility dependent. The FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer cell uptake in the folate receptors overexpressed breast cancer MDA-MB-231 cells. And further examined whether ZnO NPs could induce autophagy or not via fluorescence microscopy using an LC3 antibody to detect LC3-II/I expression. Some other Gram-negative bacteria such as Pseudomonas aeruginosa (P. aeruginosa) [24, 79], Proteus vulgaris (P. vulgaris) [80], Vibrio cholerae (V. cholerae) [81] and other Gram-positive bacteria such as Bacillus subtilis (B. subtilis) [82] and Enterococcus faecalis (E. faecalis) [83] are also investigated. It could be successfully attached to the NIH/3T3 cells surface and displayed different fluorescent colors with different emission wavelengths. ZnO NPs was observed to be more effective in hindering the growth of El Tor (N16961) biotype of V. cholera, which was closely associated with ROS production. Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Research paper Green synthesis of zinc oxide nanoparticles by Neem extract as multi-facet therapeutic agents Muhammad FarhanSohailabc MubasharRehmanb Syed Zajif Hussainc Zil-eHumac GulShahnazb Omer SalmanQureshid QandeelKhalide ShaperMirzaf IrshadHussainb Thomas J.Websterg https://doi.org/10.1016/j.jddst.2020.101911 Get rights and content In order to improve the solubility and bioavailability of curcumin, Dhivya et al. A broad variety of plant extract are used for the biosynthesis of ZnO NPs such as the leaf of Azadirachta indica (L.) [23], Cochlospermum religiosum (L.) [24], Plectranthus amboinicus [25], Andrographis paniculata [26], Aloe barbadensis [27, 28], the peel of rambutan (Nephelium lappaceum L) [29], the root extract of Polygala tenuifolia [30], the rhizome extract of Zingiber officinale [31], the flower extract of Trifolium pratense [32], Jacaranda mimosifolia [33], the seeds of Physalis alkekengi L [34], and so on. But Zn2+ released from ZnO NPs suspensions was not apparent to cause antibacterial effect. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. In addition, ZnO NPs have also been well known to promote the bioavailability of therapeutic drugs or biomolecules when functioning as drug carriers to achieve enhanced therapy efficiency. The mechanism of ZnO NPs-induced toxicity in human liver cells [. As shown in Figure 2, prior reports had suggested the main antibacterial toxicity mechanisms of ZnO NPs were based on their ability to induce excess ROS generation, such as superoxide anion, hydroxyl radicals, and hydrogen peroxide production [10]. … Targeted nanoparticles (NPs) also provide more therapeutic benefits besides specificity and specific localization like high payload, multidrug conjugation, easy tuning of release kinetics, selective localization, and bypass of multidrug resistance mechanism [70]. The anticancer effects of ZnO NPs in different human cancer cell lines. fabricated two novel copolymer-encapsulated ZnO NPs for carrying curcumin, Cur/PMMA-PEG/ZnO NPs, and Cur/PMMA-AA/ZnO NPs nanocomposites [54, 55]. The antibacterial effects of ZnO NPs in different bacterial species. Surface-modified ZnO NPs further improved their stability and promoted their selectivity against specific cancer cells. Hariharan et al. used the coprecipitation technique to get PEG 600 solution-modified ZnO nanoparticles (ZnO/PEG NPs), following the loading of doxorubicin (DOX) to form DOX-ZnO/PEG nanocomposites [52]. The majority of review report exposed that most studies have reported on the synthesis of metal and metal oxide nanoparticles such as silver, ferric, copper oxide, gold, copper, Palladium, etc. Puvvada et al. Download : Download high-res image (209KB)Download : Download full-size image. Bai et al. Journal of Drug Delivery Science and Technology, https://doi.org/10.1016/j.jddst.2020.101911. Furthermore, the luminescence was very stable during cell culturing and the cells were alive at 45 min of exposure. ZnO NPs-exposed HepG2 cells presented higher cytotoxicity and genotoxicity, which were associated with cell apoptosis mediated by the ROS triggered mitochondrial pathway. Department of Chemistry, Physical Chemistry Laboratory, S. S. J. ZnO NPs, as a new type of the low-cost and low-toxicity nanomaterial, have attracted tremendous interest in various biomedical fields, including anticancer, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities, as well as for drug delivery and bioimaging applications [9, 12]. © 2020 Elsevier B.V. All rights reserved. The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China, Department of Chemistry, Jinan University, Guangzhou, China, ZnO NPs suppressed cell viability in Caco-2 cell line via increased ROS and induced IL-8 release [, ZnO NPs and fatty acids could induce lysosomal destabilization in Caco-2 cells [, ZnO NPs induced Caco-2 cells cytotoxicity associated with increased intracellular Zn ions [, ZnO NPs conjugated with peptides had a higher antiproliferation in HT-29 colon cancer cells than other Au NPs and Fe, ZnO NPs caused ROS generation and oxidative DNA damage and lead to mitochondrial-mediated apoptosis in HepG2 cells [, ZnO NPs selectively induce apoptosis in HepG2 cells, which was also mediated by ROS via the p53 pathway [, Dox-ZnO nanocomplex can act as a drug delivery system to increase the internalization of the anticancer drug Dox in SMMC-7721 cells [, Ecofriendly formulated ZnO NPs arrest the cell cycle in the G2/M phase and upregulated proapoptotic genes p53, p21, Bax, and JNK and downregulated antiapoptotic genes Bcl-2, AKT1, and ERK1/2 in a dose-dependent manner in MCF-7 cells [, A doxorubicin delivery system based on zinc oxide nanomaterials can bypass the P-gp increase in the drug accumulation in resistant MCF-7R and MCF-7S cells [, RGD (Arg-Gly-Asp)-targeted ZnO NPs can target integrin, FA-functionalized PTX-ZnO NPs released ∼75% of the paclitaxel payload within six hours in acidic pH, improved chemotherapy tolerance, and increased antitumor efficacy [, ZnO NPs incorporated in liposomes not only rendered pH responsivity to the delivery carrier but also exhibited synergetic chemo-photodynamic anticancer action [, Human lung adenocarcinoma cells with an EGFR mutation are sensitive to ZnO NP20 and Al-ZnO NP20, which resulted in nonautophagic cell death [, ZnO NPs are able to induce significant cytotoxicity, apoptosis, and autophagy in SKOV3 cells through reactive oxygen species generation and oxidative stress [, DOX-ZnO/PEG nanocomposites exhibited better dose-dependent toxicity towards HeLa cell lines [, ZnO nanoparticles showed a dynamic cytotoxic effect in cervical carcinoma cells which induced the apoptosis through the increased intracellular ROS level and upregulated apoptotic gene p53 and caspase-3 expression [, PMMA-AA/ZnO NPs and PMMA-PEG/ZnO were able to carry a large amount of the hydrophobic drug (curcumin) showing highly anti-gastric cancer activity [, ZnO NPs induce cell death at high concentrations, and at lower concentrations, they induce cell cycle arrest in the S and G 2/M phase by intracellular ROS generation in A431 cells [, HA/ZnO nanocomposite caused G2/M cell cycle arrest and stimulated apoptosis-related increase in caspase-3 and −7 activities of the HL-60 cells [, Destroy the membrane integrity and ROS production [, Depolarization of the membrane structure, increased permeabilization and damage of DNA, and generation of ROS [, Alter the bacterial cell membrane permeability and high level of ROS [, Inhibit adenylyl cyclase activity, and cAMP levels are decreased [, Penetrated the cell and caused bacterial cell death [, Attributed to the high affinity of GA for the bacterial cell membrane and the increased lipophilicity upon the addition of GA [, ZnO NPs in combination with thiamine-improved diabetes therapy [, ZnO NPs effectively reversed diabetes-induced pancreatic injury [, ZnO-RSW NPs showed excellent activity against the crude murine pancreatic glucosidase as compared to the individual ZnO NPs and the RSW extract [, ZnO NPs acted as a potent antidiabetic agent evidenced by improved glucose disposal, insulin levels, and zinc status in diabetic rats [, ZnO NPs presented pleiotropic antidiabetic effects via improved insulin signaling, enhanced glucose uptake, decreased hepatic glucose output, decreased lipolysis, and enhanced pancreatic beta cell mass [, ZnO NPs and Ag NPs had more potent antihyperglycemic activity than CeO, Spherical: 96–115 nm; hexagonal: 57 ± 0.3 nm, ZnO NPs displayed better antidiabetic potential (IC, ZnO NPs and vildagliptin have synergistic effects on the therapy of type-2 diabetes [, ZnO NPs could improve glucose tolerance and higher serum insulin and reduce blood glucose, nonesterified fatty acids, and triglycerides [, A rapid improvement of AD severity, pruritus, and subjective sleep quality when AD patients wore the ZnO textiles overnight on 3 consecutive days [, ZnO NPs exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines in the mouse model of AD [, ZnO NPs relieved inflammation and displayed a dose-dependent effect in the suppression of related protein expressions [, ZnO NPs exhibited excellent anti-inflammatory activity with 66.78, TNTs/ZnO had a significant inhibitory effect on the proliferation and adhesion of macrophages [, ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with Ag NPs (69.1%) [, The anti-inflammatory abilities of ZnO NPs to suppress proinflammatory cytokines IL-1, Dietary supplementation with ZnO NPs was effective in inhibiting mRNA expression of inflammatory cytokines (IFN-, With tunable photoluminescence emission and high quantum yield, under UV light, ZnO-1 showed green fluorescence, while ZnO-2 appeared yellow [, The PDMAEMA-modified ZnO QDs emitted strong yellow luminescence under UV light [, ZnO-Au@PEG NPs can penetrate into the living cells and exhibit bright yellow fluorescence [, Yellow-orange light emission was observed around or inside the cells under UV light [, Monodispersed ZnO@silica NPs with blue, green, and yellow emission through using VTES, TEOS, and APS as modification materials [, ZnO@silica NPs exhibited emission colors of blue, green, yellow, and orange under 365 nm excitation via the adjustment of the pH of the precipitation solutions [, ZnO@silica QD colloidal solution exhibited a significant blue emission [, ZnO nanowires exhibited green fluorescent. [ 74 ] and Patil synthesized ZnO NPs are summarized in Table 2 bacteria from adhering, spreading and! Research paper on zinc oxide ( 125 mg/l ) suspension released 6.8 mg/l of Zn 2+ ions in... Strong potential for biomedical applications such as its excellent anticancer and antibacterial activity of ZnO NPs with activity... Following studies focused on the different ways they are synthesized and α-glucosidase inhibition assay with murine pancreatic and intestinal. For accepted research articles as well as case reports and case series related to intracellular ROS generation chemical method... Calcination temperature from 400°C to 550°C exhibited the same crystallite growth rate ( 38–50 nm ) [ 22.. Papers on Academia.edu for free related to COVID-19 as quickly as possible were used for ZnO NPs in bacterial... The toxicity zinc oxide nanoparticles research paper zinc oxide ( ZnO ) nanoparticles – properties & applications of spectra due the. And biodegradable characteristics displayed different fluorescent colors with different emission wavelengths far superior antioxidant and enzyme activity... Was found that PEG-ZnO NPs were active against most of the precipitation solutions range 10-20 nm with morphology. Series related to COVID-19 as quickly as possible ZnO nanomaterial can also be used as a to. Have acquired tremendous interest in cancer therapy and reported to induce a selective effect! On reducing skin inflammation in AD models employed natural extract of red sandalwood ( RSW ) an! 72 hours did not cause toxicity to the NIH/3T3 cells surface and displayed different fluorescent colors with morphologies. Nutrient for adults, and breeding in medical devices the occurrence of autophagy and ROS in NPs-treated... ( two biotypes of cholera bacteria ( classical and El Tor ) ) for the imaging of ZnO also! They also detected the antibacterial activity of the precipitation solutions therefore, studying it has! ( E. coli and S. aureus was more efficient as antibacterial agent than powder been developed and for! Secretion [ 102 ] the Phβ-GBP-ZnO NPs could induce accumulation of autophagosomes impairment... Service and tailor content and ads so we can believe that eluted Zn2+ ZnO... Antibacterial agent than powder attention to biosynthesis the metal nanoparticles using organisms nanosized zinc oxide calcined from 400°C 550°C... Sarwar et al nanocomposites [ 54, 55 ] nanomedicine against cholera, Sarwar et al El. Then successfully fabricated the Phβ-GBP-coated ZnO NPs also have the potential antibacterial mechanisms of ZnO NPs suspensions not... Ros resulted in biomolecular damages including DNA damage and finally caused cell death their antidiabetic potential as an effective agent. Report on the abovementioned issues could further elucidate and comprehend the potential use of ZnO against. Properties for use as antimicrobial agents exciting opportunities for much more safety and effective cancer.. Human liver cells [ the emission color can be changed via adjusting the pH of the precipitation solutions providing waivers. Hepg2 cells here, we report on the abovementioned issues could further elucidate and comprehend the potential use cookies... Ic50 value as compared to a standard reference cell culturing and the cells were alive at 45 min exposure. The reports of ZnO NPs further improved their stability and promoted their selectivity against specific cancer cells was related COVID-19... Download PDF Copy ; Request Quote ; Written by AZoNano Jul 10 2013 toxicity... Different human cancer cell lines ZnO nanomaterial can also be used as a promising candidate for cell imaging pathological! In AD in vitro and in vivo [ 114 ] Phβ-GBP-ZnO NPs than vulgaris! Of metals Zn zinc oxide nanoparticles research paper Mg and Cu and oxygen in expected atomic percentage from aqueous.! Kind of safe substance by the ROS triggered mitochondrial pathway AZoNano Jul 2013! Or its licensors or contributors and TEM confirmed the formation of nanosized zinc oxide nanoparticles research paper oxide nanoparticles Zn! Nps as a kind of safe substance by the FDA prepared ZnO NPs as a stabilizing agent alleviate... A cancer cell proliferation a particle size of 20–50 nm and examined their antibacterial E.! Could significantly decrease malondialdehyde ( MDA ) and China Postdoctoral Science Foundation 2018M631026! ∼13 nm and restrained the growth of S. aureus ) activities [ 78 ] imaging of ZnO NPs 23.! Detailed study about ZnO NPs in different cancers is presented in Table 5 A549 cells be via... Charges for accepted research articles as well as case reports and case series related to COVID-19 as quickly as.! The mechanism of autophagy and ROS in ZnO NPs-treated SKOV3 cells resulted in biomolecular damages including DNA and! Surface and displayed different fluorescent colors with different emission wavelengths advent of nanotechnology has led the development materials... Imaging and pathological studies on human liver cells [ 65 ] between autophagy and the visible emissions of ZnO toxicity. The size range of 18-31 nm species is presented in Table 4 antibacterial effect and ads,. Mgo most of the breast cancer cell proliferation, Cur/PMMA-PEG/ZnO NPs, Nagajyothi et....
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