Found insideThe purpose of this book is to show several reviews and original investigations related with osteoporosis. This volume brings together an array of chapters from many of the foremost authorities and researchers in this area. Found inside – Page 358Therefore, obesity caused by these mutations in humans would not be common. ... Study of these genes led to the identification of the leptin/melanocortin ... This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields Found inside – Page 14Cloning of the ob gene and characterization of leptin Recessive mutations in the mouse ob and db genes result in obesity and diabetes in a syndrome resembling morbid human obesity [1]. Affected ob and db mice have identical phenotypes, ... The results of this meeting are presented in this book. PWS results from a paternally derived deletion or an imprinting defect on chromosome 15. Found inside – Page 423Leptin and Leptin Receptor Mutations Cause Obesity in Humans Mutations in the human LEP gene were first identified in children of a consanguineous Pakastani ... Found inside – Page 69Similarly, in 199622,23 mutations in the leptin receptor were identified as the determinant of obesity and diabetes in the db/db strain. Leptin is one of a ... Found inside – Page 52On the other hand, lymphocytic hypophysitisis a rareinflammatory disease that ... Hypogonadotropic hypogonadism is therefore caused by leptin gene mutation ... Found inside – Page 2845Leptin was serendipitously discovered as the gene defect responsible for the phenotype of morbid obesity and type II diabetes in spontaneously mutated ob/ob ... Found insideThese models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. Familial hypercholesterolemia and childhood obesity both contribute to elevated serum cholesterol levels resulting in the accelerated progression of atherosclerosis in children. This book provides summaries of the evidence from the literature as well as the Working Group's conclusions and recommendations to tackle the global epidemic of obesity. Found insideThis book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management. Found insideThis book aims to provide an update in the current state of play in pancreatic cancer diagnosis and to evaluate the benefits and limitations of the available diagnostic technology and therapy. Found inside – Page 1Distinguished experts, who have published extensively in their fields, have contributed comprehensive chapters to this volume. With an increased focus on new practice concepts, such as stratified, personalized and precision medicine, this book is a valuable and much-needed resource that unites the core principles of molecular biology with the latest and most ... In this text, contributors from the field of evolutionary biology, peptide chemistry, pigmentation biology, neuroscience, endocrinology and genetics provide the reader with a comprehensive review of melanocortin biology. Found insideThis is the first edition of the book so it covers the introductory level of topics which are ideal for veterinary students, classroom use, and practitioners who require more guidance with genetics. Edited by world-renowned bariatric surgeons, this comprehensive reference provides a clear overview of multidisciplinary approaches to bariatric surgery and clearly details the techniques and outcomes of commonly performed bariatric ... The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models ... This stellar reference work focuses on nearly 500 endocrine diseases addressing everything from acromeglay, diabetes, hypertension, osteoporosis, thyroid disease, Von Hippel-Lindau Disease, unexplained weight loss, to androgen related ... This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. This title looks at the spread of obesity worldwide. Found inside – Page 200Table 13.1 Genes involved in animal model obesity Animal strain Gene(s) involved Cardiac ... By a single mutation in the leptin gene or the leptin receptor, ... In this book, internationally recognized experts review the most important advances regarding the group of human developmental disorders caused by constitutive dysregulation of the Ras-MAPK signalling pathway, including Noonan, ... Found inside – Page 47Nevertheless, a few ob and db mutations have been described by other investigators. Two cousins homozygous for a frameshift mutation in the leptin gene are ... This book is an edited collection of the literature on leptin beginning with the discovery of leptin and a study of its affect on animals and in humans. Found inside – Page 183Mazen I, El-Gammal M, Abdel-Hamid M, Amr K. A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient. Mol Genet Metab. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but ... Found insideAdiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. Found insideThis book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. The American Obesity Association identifies obesity's link to numerous medical conditions, including hypertension, type 2 diabetes, cardiovascular disease, several cancers, and a host of inflammatory disorders. Found insideExploring the history of our food, debunking marketing nonsense, detoxifying diet advice, and confronting the advocates of clean eating, Giles translates his pioneering research into an engaging, must-read study of the human appetite.In a ... Highly Commended in the 2006 British Medical Association Book Awards (Endocrinology) This Second Edition brings together more than 20 internationally recognized experts in the field to provide a timely review of current knowledge. This volume takes an integrative approach to obesity. This book aims to increase physicians knowledge and understanding of obesity in childhood and adolescence as well as to further public awareness of the health burden and economic dimension of obesity at a young age. This volume brings together leading experts in comparative and evolutionary psychology. Found inside – Page 148In several adipocyte genes, mutations and polymorphisms have been reported which may modify human obesity and cardiovascular risk. 6.20.1 Leptin Gene ... Found inside – Page 498Single-Gene Mutations in Mouse Models of Obesity and Their Role in Human Obesity Human Mutation Chromosome Gene Gene Product Obese (ob) 7q31.1 IEP Leptin ... Found insideThis book is the second in a series of two, featuring the Adiposity - Omics and Molecular Understanding, serving as an introduction to modern views on how the adipocytes are reciprocally interacting with organ systems in order to explain ... Found inside – Page iiiLeptin and Reproduction is the first major volume to specifically address leptin as a reproductive hormone and closely examines the advances made in the short time since this field of interest developed. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone. Found inside – Page 138Leptin deficiency or leptin receptor abnormalities are exceedingly rare. ... only 3% had mutations in the leptin receptor gene.88 There have been six ... Found inside – Page 185Mutation of the POMC gene causes single-gene obesity in humans. ... Mendelian obesity in humans: leptin (gene abbreviation, LEP), leptin receptor (LEPR), ... However, it is clear that drugs are an essential element of the therapy and this issue is analyzed extensively in this book. Some novel pathophysiological mechanisms are also presented, offering advanced knowledge to the reader. Found inside – Page 1749.12.1 Leptin gene mutations Mutations in the leptin gene and its receptor have been reported, and are associated with obesity and hyperphagia in both mice ... Found insideObesity in the Early Childhood Years summarizes the presentations and discussions from the workshop. Found insideProviding a comprehensive overview of the key literature in this field, Advanced Nutrition and Dietetics in Obesity is an invaluable resource for all those whose work should or does embrace any aspect of obesity. To lipotoxicity researchers in this book and db mutations have been reported which may modify human obesity and cardiovascular.. Discussions from the workshop found inside – Page 358Therefore, obesity caused by these mutations in would... 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